The increase in age and the duration of testosterone use significantly reduce the likelihood of sperm recovery in the ejaculate, based on the criteria of a TMC of 5 million spermatozoa, at 6 and 12 months. Physicians should be careful about long-term testosterone treatment, especially in men who still want to be fertile. With these findings, doctors can advise men about the likelihood of sperm recovery at 6 and 12 months. Mills and collaborators evaluated the recovery of spermatogenesis after the administration of exogenous testosterone in 26 men with a recent history of anabolic steroid use (1).
All stopped using exogenous testosterone and were treated with hCG 3000 units intravenously every other day for a minimum of 3 months. Of the two men who remained azoospermic, one had insufficient follow-up and the other was suspected of continuing to use anabolic steroids. Men who were taking testosterone intramuscularly at the time of presentation recovered spermatogenesis in an average of 3.1 months. However, men who received transdermal testosterone supplements at the time of presentation took an average of 7.4 months.
The authors concluded that the deterioration of fertility following the suppression of TRT is reversible and that the sperm rate may be related to the delivery system. It's common for men who receive TRT to experience a significant decline in fertility and have difficulty conceiving because of a low or no sperm count. This is how men can become sterile by taking testosterone. In most cases, this infertility is temporary.
The effects can be reversed by discontinuing TRT and waiting for internal testosterone and sperm levels to rise again. This process can take six weeks, six months, or a couple of years. However, some men never regain their fertility at all. Exogenous testosterone therapy decreases sperm production and has detrimental effects on male fertility. In the final model, six independent variables were used: three continuous variables (duration of TTH, age at discontinuation and level of testosterone at the time of presentation) and three categorical variables (if TTh was administered by intramuscular injection, transdermal application or granule insertion; use of clomiphene or tamoxifen citrate; and presence of cryptozoospermia or azoospermia).
Aromatase inhibitors have been used to treat men with Klinefelter syndrome to normalize serum testosterone levels before microscopic removal of testicular sperm. The exogenous administration of synthetic testosterone produces negative feedback in the hypothalamic-pituitary axis, which inhibits GnRH and inhibits the production of FSH and LH. The addition of low doses of hCG maintained ITT levels, while the administration of testosterone alone resulted in a profound decrease in the concentration of ITT. You have been taking an intramuscular testosterone medication (IM-T) for the treatment of symptomatic hypogonadism.
A major problem is that the literature evaluates the use of testosterone therapy as a male contraceptive agent. Although less commonly used in the general population, hCG therapy with or without testosterone supplements represents an alternative treatment.
After a mean follow-up of 6 months, no patient became azoospermic during concurrent testosterone and hCG replacement therapy.
In these cases, doctors should be aware of the pathophysiological disorders of the HPG axis related to the use of TRT or ASA and the drugs available for reverse them. Men were instructed to discontinue the use of testosterone and begin a regimen of 3000 IU of hCG administered subcutaneously three times a week.In a pooled analysis of 30 studies using testosterone as a short-term hormonal contraceptive in eugonadal men, Liu et al. In turn, the pituitary secretes follicle stimulating hormone (FSH) and luteinizing hormone (LH), which indicate the production of sperm and testosterone in the testes.
