The effects on quality of life appear within 3 to 4 weeks, but maximum benefits take longer. The increase in energy and stamina begins to occur after about 3 months. After that, you'll notice continuous improvement for many weeks. During the first week, your body is getting used to the new medication and increased testosterone levels. Many of the benefits of TRT take weeks or months to fully appear.
If patients have not been exposed to testosterone at the usual time of puberty, they should be prepared and counseled about the onset of sexual thoughts and dreams, about increased erections and seminal emissions, and about when to expect them. In conclusion, this analysis seeks to trace the differences in the periods of time after which the biological effects of testosterone administration occur in hypogonadal men. Millions of men use testosterone replacement therapy to restore low levels and feel more alert, energetic, mentally sharp and sexually functional. In judging the temporal evolution of the effects of testosterone on the prostate, it should be noted that aging itself is a factor in increasing both prostate volume and PSA (8), and there is no end point for the effects of testosterone on the prostate.
The positive effects of testosterone on depressive symptoms are most likely to begin as soon as 3 to 6 weeks, but it will most likely take 18 to 30 weeks before significant improvement is detected in the patient. The Endocrinology Society's clinical practice guidelines for testosterone treatment suggest an alternative of 75 to 100 mg intravenously per week or 150 to 200 mg intravenously every 2 weeks (. In a study that combined testosterone with growth hormone, total lean body mass increased, as did lean appendicular tissue. Almost all of these studies were not specifically designed to address the onset or temporary dependence of the effects of testosterone; however, several controlled studies with a different design and scheduled follow-up allow for a reasonable estimate.
Doctors diagnose low testosterone levels based on a physical exam, a review of symptoms, and the results of several blood tests, as levels can fluctuate daily. There is a certain degree of consensus that older men with serum testosterone levels clearly below the reference limits and with clear and persistent clinical signs of hypogonadism can justifiably receive treatment (98, 9), but there remains a high degree of disagreement. Asymmetric dimethylarginine is an endogenous NO synthase inhibitor and appears to decrease with testosterone administration after 10 days (6) or after 4 weeks (6). In addition to the time course of testosterone's actions on androgen-dependent biological variables, Table 1 presents an indication of the quantitative changes associated with testosterone administration. The search was limited to tests conducted with testosterone, including testosterone esters and dihydrotestosterone preparations, regardless of childbirth.
The latter varies inversely with the initial testosterone concentration and predicts the magnitude and speed of the response to treatment. The improvement in insulin sensitivity after the administration of testosterone resulted in a reduction in fasting glucose and insulin levels within a single week (50), corroborating previous reports of increased insulin sensitivity after endogenous testosterone stimulation within 48 hours (4) and a sharp reduction in insulin sensitivity 2 weeks after discontinuing testosterone replacement in men with severe hypogonadia (5). Most men feel an improvement in symptoms four to six weeks after taking testosterone replacement treatment, although there are changes such as increased muscle mass. It can take three to six months.
