Taking higher doses of hormones won't necessarily cause faster changes, but it could endanger your health. And because everyone is different, you. Consider the effects of hormone therapy as if it were a second puberty, and puberty usually takes years to fully notice. In addition, because everyone is different, your medications or doses may vary considerably from those of your friends or those you may have read in books or online forums.
Be careful when reading about hormonal regimens that promise specific, rapid, or drastic effects. While it is possible to adjust medications and doses to achieve certain specific goals, the way the body changes in response to hormones depends more on genetics and the age at which you start taking it, than on the specific dose, route, frequency, or types of medications taken.
Testosterone replacement
therapy (TRT) is a treatment that is widely used in men with symptomatic hypogonadism. The benefits of TRT, such as increased libido and energy level, beneficial effects on bone density, strength and muscles, and cardioprotective effects, are well documented. TRT is contraindicated in men with untreated prostate and breast cancer.Men treated with TRT should be monitored for side effects such as polycythemia, peripheral oedema, and heart and liver dysfunction. Compared to conventional treatment with testosterone enanthate or cypionate, which requires injection intervals of 2 to 3 weeks and produces serum levels of supraphysiological testosterone, testosterone undecanoate (TU) injections at intervals of up to 3 months offer an excellent alternative for replacement treatment of male hypogonadism. The indication for testosterone replacement therapy (TRT) requires the presence of a low level of testosterone and the presence of symptoms and signs of hypogonadism. Men start with testosterone replacement and feel better, but then it's hard to stop doing it.
At the same time, many studies271 to 273 have not demonstrated a significant exacerbation of urination symptoms attributable to benign prostatic hyperplasia during testosterone supplementation, and there have been no complications such as urinary retention at higher rates than in placebo-receiving controls, nor was there any difference in urine flow rates, post-mictional residual urine volumes, and symptoms of prostatic urination with patients who received treatment in these studies. Because of this risk of polycythemia, men who undergo TRT should not only monitor their complete blood count (CBC) during treatment, but should also have a baseline blood count taken before starting treatment with testosterone. Until recently, testosterone cypionate and enanthate were frequently used by intramuscular injection of short-acting testosterone esters, which usually produce supraphysiological peaks and hypogonadal valleys in testosterone levels. Serum testosterone varies during the day and levels peak between 08:00 and 10:00 hours, so a serum sample should be obtained between 07.00 and 11.00 hours.
At a median of 19 months of TRT, hypogonadal patients with a history of prostate cancer had no recurrence of PSA and had statistically significant improvements in total testosterone and hypogonadal symptoms. In men undergoing hormone therapy for prostate cancer, the suppression of endogenous testosterone synthesis and androgen receptor blockade resulted in a beneficial effect on verbal memory, but an adverse effect on spatial capacity188 and on visuomotor slowdown and reaction times in various domains of attention; 189 plasma amyloid levels increased as T levels decreased. These fluctuations in testosterone levels can cause variations in libido, sexual function, energy and status of encouragement.
